Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Isothiocyanates are compounds found naturally in cruciferous vegetables like mustard, horseradish, and wasabi. Traditionally, preparations from these plants have been used in various cultures as home remedies for respiratory ailments, including coughs—particularly those described as "spastic" or related to bronchial irritation. The pungency and volatility of isothiocyanates are believed to stimulate mucous membranes, potentially increasing salivation and secretion in the respiratory tract, which can help loosen mucus and ease coughing. For example, mustard plasters and horseradish syrups have a long history of folk use for cough relief in Europe and Asia.

However, direct scientific evidence supporting isothiocyanates' efficacy specifically for spastic cough is limited. There is some experimental data showing mild expectorant and mucolytic effects of these compounds, and their antimicrobial activities may also play a role in traditional applications. Still, rigorous clinical trials evaluating isothiocyanates as a treatment for cough—especially of the spastic variety—are lacking. Thus, the use of isothiocyanates for cough is primarily justified by traditional and historical practices rather than robust scientific validation.

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