Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Glycyrrhetinic acid is a bioactive compound derived from glycyrrhizin, the main sweet-tasting constituent of licorice root (Glycyrrhiza glabra). Licorice and its extracts have a long history of use in traditional medicine systems, especially Traditional Chinese Medicine (TCM), for soothing dry coughs and alleviating irritation of the throat. In TCM, licorice is often included in herbal formulas to moisten the lungs and relieve cough. The mechanism is believed to involve its demulcent and anti-inflammatory properties, which may help soothe mucous membranes.

While glycyrrhetinic acid is a key metabolite thought to contribute to some of licorice's effects, direct evidence for glycyrrhetinic acid itself as an antitussive is limited. Most scientific research has focused on its anti-inflammatory and antiviral actions rather than cough suppression. Some preclinical studies suggest glycyrrhetinic acid can modulate inflammatory pathways and may support mucosal healing, but robust clinical evidence for its use in dry cough is lacking. Thus, its use for dry cough is primarily justified by traditional practice rather than rigorous scientific validation.

In summary, the support for glycyrrhetinic acid in treating dry cough is rooted in traditional herbal medicine, particularly through the use of licorice extracts, rather than direct modern scientific evidence.

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