Evidence supporting the use of: Withanolides
For the body system: Cortisol

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Withanolides are a group of naturally occurring steroidal lactones primarily found in the plant Withania somnifera (Ashwagandha). Their use to support the cortisol body system is principally based on scientific studies, although traditional medicine has also used Ashwagandha for stress and vitality. Modern research has demonstrated that withanolides possess adaptogenic properties, meaning they help the body adapt to stress and normalize physiological processes, including cortisol regulation. Several randomized, placebo-controlled human trials have shown that standardized Ashwagandha extracts containing withanolides can reduce perceived stress and lower serum cortisol levels in stressed individuals. For example, a 2012 study published in the "Indian Journal of Psychological Medicine" found significant reductions in cortisol and stress scores in participants taking Ashwagandha extract compared to placebo. Meta-analyses and systematic reviews conducted in recent years have generally concluded that Ashwagandha supplementation has a moderate effect in reducing stress and cortisol, though more large-scale and long-term studies are needed for definitive conclusions. Overall, the evidence supporting withanolides' role in supporting the cortisol system is moderate and primarily based on their adaptogenic and stress-lowering effects as shown in human clinical research.

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Products containing Withanolides

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