Evidence supporting the use of: Eleuthero Root
For the body system: Cortisol

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Eleuthero root (Eleutherococcus senticosus), commonly known as Siberian ginseng, has a long history of use in traditional Chinese and Russian medicine as an adaptogen—a substance believed to help the body resist physical, chemical, and biological stress. Scientific research, primarily from Russia and Asia, has explored Eleuthero’s potential to modulate the body’s stress response, particularly via the hypothalamic-pituitary-adrenal (HPA) axis, which controls cortisol production. Several animal and limited human studies suggest that Eleuthero extract may help normalize cortisol levels and improve the body’s adaptation to stress. For example, a small number of placebo-controlled trials have shown benefits in reducing fatigue and improving mental performance under stress, outcomes possibly linked to cortisol modulation. However, the quality and consistency of studies vary, with most being small-scale and sometimes lacking rigorous methodology. Systematic reviews acknowledge Eleuthero’s adaptogenic effects but emphasize the need for larger, well-designed human studies to confirm efficacy and clarify mechanisms. In summary, while the use of Eleuthero root to support the body’s stress response and cortisol regulation is backed by a combination of traditional use and preliminary scientific evidence, the overall body of scientific data is moderate, warranting a rating of 3 on the evidence scale.

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