Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B3, which includes niacin (nicotinic acid) and niacinamide (nicotinamide), is scientifically recognized as an essential nutrient involved in numerous metabolic processes, particularly those related to energy production and cellular repair. During convalescence—the recovery period following illness, surgery, or injury—the body’s metabolic demands are often increased, and nutritional status can be compromised, especially if appetite or absorption has been affected. Vitamin B3 plays a key role as a precursor for NAD and NADP, cofactors required for cellular energy metabolism and tissue repair. Deficiency in vitamin B3 is known to cause pellagra, characterized by weakness, dermatitis, diarrhea, and neuropsychiatric symptoms, which can further hinder recovery.

While there is no robust, direct clinical trial evidence specifically demonstrating that supplemental vitamin B3 accelerates or enhances recovery during convalescence in individuals with adequate dietary intake, it is standard nutritional practice to ensure adequate intake of all B vitamins, including B3, during this period. This is based on the scientific understanding of its biochemical roles and the potential for deficiency during illness or poor nutritional states. Historical use of vitamin B3 during recovery from conditions associated with malnutrition or increased metabolic demand further supports its use. However, the specific benefit of supplementation beyond correcting deficiency is not strongly substantiated by high-quality evidence, which is reflected in the moderate evidence rating.

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