Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Glutamine, an amino acid, is well-studied for its role in recovery and convalescence, particularly after illness, surgery, trauma, or periods of severe stress. During convalescence, the body's demand for glutamine increases due to its role in supporting immune cell function, maintaining intestinal barrier integrity, and serving as a substrate for rapidly dividing cells. Several clinical studies and systematic reviews have evaluated glutamine supplementation in hospitalized and critically ill patients. Evidence suggests that glutamine supplementation can help reduce infection rates, support gut health, and may shorten hospital stays in certain populations, such as surgical or trauma patients. However, results are mixed, and benefits are most pronounced in patients with specific needs, such as those with major burns, gastrointestinal surgery, or severe catabolic stress. The European Society for Clinical Nutrition and Metabolism (ESPEN) and other clinical guidelines recognize glutamine’s potential benefits in selected patient groups, although routine use is not universally recommended for all patients. In summary, there is moderate scientific support for the use of glutamine as a supplement during convalescence, especially in cases where metabolic demand is high, but further research is warranted to determine the optimal use and patient populations that benefit most.

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