Evidence supporting the use of: Astragaloside
For the health condition: Congestive Heart Failure

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Astragaloside, a key active component of Astragalus membranaceus, has been used in Traditional Chinese Medicine (TCM) for centuries, particularly in formulas intended to support cardiovascular health and treat symptoms resembling congestive heart failure (CHF). The traditional rationale is based on the concept of "Qi" tonification, where Astragalus is believed to strengthen the body's vital energy, improve circulation, and reduce edema—all symptoms potentially seen in heart failure.

Scientifically, a handful of preclinical studies and small-scale human trials suggest that extracts of Astragalus may have some cardioprotective effects, such as improving cardiac function, reducing oxidative stress, and modulating inflammation. However, the majority of clinical research is limited in quality—often lacking adequate controls, blinding, or sufficient sample sizes. Most clinical trials combine Astragalus with standard heart failure medications, making it difficult to isolate the effect of astragaloside itself. Systematic reviews and meta-analyses indicate possible symptomatic improvement (such as fatigue and exercise tolerance), but emphasize the need for more rigorous, large-scale studies.

In summary, the use of astragaloside for CHF is primarily justified by traditional use, with limited and low-quality scientific evidence supporting its efficacy. It should not be considered a substitute for established heart failure treatments.

More about Astragaloside
More about Congestive Heart Failure

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