Evidence supporting the use of: DHA (docosahexaenoic acid)
For the health condition: Confusion

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is a critical structural component of the human brain, retina, and other neural tissues. Scientific interest in DHA's effects on cognitive health stems from its high concentration in neural membranes and its role in synaptic function. There is moderate scientific evidence suggesting that DHA supplementation may support cognitive function, including symptoms related to confusion, particularly in specific populations such as the elderly or those with mild cognitive impairment.

Several observational studies have found associations between low DHA intake or blood levels and an increased risk of cognitive decline. Some randomized controlled trials (RCTs) have shown that DHA supplementation can modestly improve cognitive function or slow decline in certain populations, but the effects are generally small. For example, a 2010 RCT published in "Alzheimer's & Dementia" found no significant benefit in Alzheimer's patients, but some studies in older adults with mild memory complaints reported modest improvements in cognitive performance.

It is important to note that "confusion" as a symptom can have many causes beyond neurodegeneration, and the evidence for DHA's effectiveness is not robust across all causes of confusion. While DHA is not a primary treatment for acute confusion (delirium), it may play a role in supporting long-term brain health and function. Thus, the scientific validation for DHA use to treat or support confusion is limited but present, supporting a moderate rating.

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