Phosphatidylserine (PS) is a phospholipid found in high concentrations in the brain and is critical for cell membrane integrity and signaling. Its use for supporting concentration, particularly in people experiencing age-related cognitive decline or attention problems, is backed by some scientific evidence, though the strength of this evidence is moderate.

Multiple randomized controlled trials have demonstrated that phosphatidylserine supplementation (typically 100-300 mg daily) may improve cognitive functions, including attention, memory, and processing speed, especially in elderly individuals with mild cognitive impairment. For example, a 2001 double-blind study published in the journal Aging found that older adults receiving PS showed improvements in attention and memory compared to placebo. Another study in Journal of Human Nutrition and Dietetics (2010) indicated that PS supplementation improved attention-deficit hyperactivity disorder (ADHD) symptoms in children.

The mechanism is thought to involve support of neuronal membrane fluidity, receptor function, and neurotransmitter release. However, studies in healthy young adults are limited and results are mixed, with some trials showing modest benefit and others showing no significant effect. Overall, while there is a scientific basis for using phosphatidylserine to support concentration, especially in populations with cognitive deficits, the evidence is not uniformly strong across all age groups or conditions. More large-scale, high-quality research is needed to firmly establish efficacy.