Evidence supporting the use of: Hydroxyanthracene derivatives
For the health condition: Colon (atonic)
Synopsis
Source of validity: Traditional
Rating (out of 5): 3
Hydroxyanthracene derivatives, found in plants such as senna (Senna alexandrina), cascara (Rhamnus purshiana), and aloe, have been used traditionally as stimulant laxatives to treat various forms of constipation, including atonic colon (a condition characterized by reduced muscle tone in the colon, leading to sluggish bowel movements). The use of these derivatives dates back centuries in both Western and traditional medicine systems. Their primary mechanism involves stimulation of colonic motility by increasing peristalsis through direct action on the intestinal wall, as well as altering water and electrolyte secretion in the colon, resulting in softer stools and enhanced bowel movement.
While there is strong traditional use and some clinical evidence supporting their efficacy as laxatives in the short term, particularly for acute or occasional constipation, robust modern clinical trials specifically targeting "atonic colon" are limited. Most studies focus on general constipation. Because atonic colon is a form of chronic constipation, the use of hydroxyanthracene derivatives is often extrapolated from broader constipation studies. Regulatory bodies, such as the European Medicines Agency, recognize their use for short-term relief of occasional constipation, but caution against long-term use due to potential adverse effects such as electrolyte imbalance and risk of dependence.
In summary, the use of hydroxyanthracene derivatives for atonic colon is justified primarily by tradition, with moderate supporting evidence for their laxative effects in general constipation, but limited high-quality data specific to atonic colon.
More about hydroxyanthracene derivatives
More about Colon (atonic)
Other health conditions supported by hydroxyanthracene derivatives
Colon (atonic)Colon (spastic)
Constipation (adults)
Constipation (children)
Digestion (poor)
