Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Hericium erinaceus (Lion's Mane mushroom) has been studied for its potential to support and treat colitis, particularly in preclinical settings. The primary evidence comes from animal studies and in vitro experiments rather than extensive human clinical trials. Several animal models of colitis (such as dextran sulfate sodium-induced colitis in mice) have demonstrated that extracts from Hericium erinaceus mycelium or fruiting bodies can reduce markers of inflammation, preserve colon tissue integrity, and modulate immune responses. The presumed mechanisms include downregulation of pro-inflammatory cytokines (e.g., TNF-α, IL-6), upregulation of anti-inflammatory pathways, antioxidant activity, and possible modulation of the gut microbiota.

A few small-scale human studies have explored the anti-inflammatory effects of Hericium, but direct, high-quality clinical evidence for its use in colitis patients is lacking. Traditional use of Hericium in East Asian medicine has been more focused on gastrointestinal wellness generally, such as for ulcers or gastritis, rather than colitis specifically. Thus, while preclinical data support a plausible benefit, clinical validation is insufficient at this time, warranting a modest evidence rating of 2 out of 5.

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