Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Isothiocyanates are sulfur-containing compounds found in cruciferous vegetables such as mustard, horseradish, and wasabi. Their use in supporting or treating colds is not primarily rooted in traditional medicine but has some scientific basis. Research has shown that certain isothiocyanates, such as allyl isothiocyanate and sulforaphane, possess antimicrobial and antiviral properties in vitro. For example, studies have demonstrated that these compounds can inhibit the replication of specific viruses, including influenza, by interfering with viral entry or replication mechanisms. Moreover, isothiocyanates may enhance cellular antioxidant defenses by activating the Nrf2 pathway, which could theoretically support immune function and the body's response to viral infections.

However, clinical evidence in humans is limited. Most studies are either preclinical or involve animal models, and there is a lack of high-quality randomized controlled trials directly assessing the effect of isothiocyanates on the common cold or other respiratory viral infections in humans. As such, while laboratory data suggest potential antiviral activity, the current level of evidence supporting the use of isothiocyanates for colds is weak and not sufficient for firm clinical recommendations. Further research, particularly in human subjects, is required to substantiate these preliminary findings.

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