Evidence supporting the use of: Alpha lipoic acid
For the health condition: Circulation (to the brain)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha lipoic acid (ALA) has modest scientific support for its use in promoting circulation, including cerebral (brain) circulation, though the evidence is not robust. ALA is a naturally occurring antioxidant that plays a role in mitochondrial energy metabolism. Its potential effects on circulation stem from its antioxidant properties, ability to reduce oxidative stress, and improvement of endothelial function. There is evidence that ALA supplementation can enhance blood flow and vascular health, primarily in the context of diabetic neuropathy and peripheral artery disease. Some small clinical studies and animal research suggest that ALA can improve endothelial-dependent vasodilation and reduce markers of vascular inflammation, which could theoretically benefit cerebral circulation. However, direct scientific evidence supporting the use of ALA specifically for improving circulation to the brain in healthy individuals or in those with cerebrovascular disorders is limited. ALA is more commonly studied for its neuroprotective effects, which may be indirectly related to improved cerebral circulation due to reduced oxidative damage. A 2011 review in CNS & Neurological Disorders - Drug Targets highlighted ALA's potential neurovascular benefits but emphasized the need for larger, well-controlled trials. In summary, while the mechanistic rationale and some preliminary studies support the use of ALA for vascular health, the direct evidence for its use in enhancing circulation to the brain is modest and more research is needed.

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