Evidence supporting the use of: Oligomeric proanthocyanidins
For the health condition: Circulation (poor)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Oligomeric proanthocyanidins (OPCs), a class of polyphenolic compounds found primarily in grape seeds, pine bark, and certain other plants, have been studied for their potential benefits in supporting circulation and vascular health. Scientific evidence indicates that OPCs exert vascular protective effects primarily through antioxidant, anti-inflammatory, and vasodilatory actions. Clinical trials and experimental studies have shown that OPCs can strengthen capillary walls, reduce capillary permeability, and improve venous tone, which may be beneficial for individuals with chronic venous insufficiency or poor circulation. For instance, standardized extracts such as grape seed extract and Pycnogenol® (French maritime pine bark extract) have demonstrated improvements in symptoms such as leg heaviness, swelling, and cramps in patients with chronic venous insufficiency in randomized controlled trials.

Mechanistically, OPCs are believed to enhance endothelial function by increasing nitric oxide availability and protecting blood vessels from oxidative stress. Some studies also suggest a role in reducing platelet aggregation, which may aid microcirculation. However, while there is a moderate body of clinical evidence supporting their benefit, the overall quality and size of studies vary, and more large-scale, high-quality trials are needed to conclusively establish efficacy. Thus, the use of OPCs for supporting poor circulation is scientifically justified, but the evidence base, while promising, is not definitive.

More about Oligomeric proanthocyanidins
More about Circulation (poor)

Other ingredients used for Circulation (poor)

acetyl l-carnitine
ajoene
algal oil
alpha-linolenic acid (ALA)
amino acids
anthocyanins
arjun tree
ashwagandha
asparagus
astaxanthin
astragalus
beet
bergamot
berry flavor
bilberry
black cumin
black currant
black garlic
black pepper
sesame
black tea
blueberry
bromelain
bupleurum falcatum
burdock
butcher's broom
caffeine
capsaicinoids
cat's claw
caterpillar mushroom
celery
chen pi
cherry
Chinese salvia root
chokeberry
cinnamon
citrus bioflavonoids
citrus sinensis (proprietary)
clove
coenzyme Q10 (CoQ10)
coleus forskohlii
cordyceps
turmeric
curcumin
d-alpha tocopherol
DHA (docosahexaeonic acid)
diallyl disulfide (DADS)
diallyl trisulfide (DATS)
dong quai root
eleuthero
EPA (eicosapentaenoic acid)
fish oil
fish protein
flavonols
flaxseed
fruit and vegetable blend (proprietary)
garlic bulb
ginger
ginkgo biloba
ginseng
gooseberry
gotu kola
grape
onion
green tea
greens blend (proprietary)
hawthorn
hesperetin
hesperidin
hibiscus
horse chestnut
horseradish
Indian tinospora
iron
knotweed
kudzu
l-arginine
l-carnitine
l-citrulline
lovage
mackerel
magnesium
marine lipid
moringa
mustard seed
naringin
nattokinase
nettle
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
orange
oyster mushroom
pine bark
policosanol
pomegranate
quercetin
redcurrant
reishi mushroom
resveratrol
rhizome
rose hips
rosemary
rutin
safflower oil
sardines
shiitake mushroom
black ginger
spinach
tocotrienols
triphala
ubiquinol
vegetable and fruit blend (proprietary)
vegetable blend (proprietary)
vitamin B
vitamin E
seaweed
water
watercress
watermelon
mulberry
sarsaparilla
suma
jiaogulan
tangerine
gastrodia
cardamom
atractylodes
capsicum
Indian bael
inula racemosa
punarnava
commiphora
smilax
blackboard tree
caesalpinia crista
peony
lingzhi
lingusticum wallichii
prickly ash
siler root
cistanche
dioscorea
dodder
ganoderma
morinda
zanthoxylum
birch
polyphenols
purslane
yerba mate
biota seed
goji berry
herbal blend (proprietary)
Sichuan pepper
yohimbe
cocoa
AMP-activated protein kinase (AMPK)
enzymes blend (proprietary)
cayenne pepper
ashitaba
2-(nitrooxy)ethyl 2-amino-3-methylbutanoate
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Aralia
Arjuna
Arginine Alpha Ketoglutarate
Antler
Autumn elaeagnus
Arginine Creatine
Arginine nitrate
Angelica
Aronia melanocarpa
Allicin
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Achyranthes
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Adrenergic amines
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Astragaloside
anthocyanidins
Asteracea
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Alliin
anthocyanosides
Allium tuberosum
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Atractylone
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Black galingale
berry
Bur-Reed
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Bassia scoparia
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Chocolate
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cola nut
Currant
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Danshen
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Date
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Garlic
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Mustard
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Pistachio
Sumac
Sweet Orange alcohol
yohimbine
Zucchini

Products containing Oligomeric proanthocyanidins

We currently have no products on Caring Sunshine that contain this ingredient.