Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Citrulline alpha-ketoglutarate (CAKG) is a compound commonly used in sports supplements, combining the amino acid citrulline with alpha-ketoglutarate. The primary rationale for using citrulline for circulation is based on its role as a precursor to arginine, which in turn is a substrate for nitric oxide synthesis. Nitric oxide acts as a vasodilator, helping to relax blood vessels and improve blood flow. Some studies have shown that supplementation with L-citrulline can increase plasma arginine levels more effectively than arginine itself, potentially improving endothelial function and blood flow, especially in individuals with compromised vascular health.

However, the specific combination of citrulline with alpha-ketoglutarate has not been studied as extensively as citrulline malate or L-citrulline alone. The evidence for citrulline (in any form) on circulation in healthy individuals is limited, and most studies focus on exercise performance rather than treating clinically poor circulation. There are a few small clinical trials suggesting benefit in populations with endothelial dysfunction, but overall, the clinical evidence is modest. The addition of alpha-ketoglutarate is hypothesized to support energy metabolism, but direct evidence of improved circulation from CAKG itself is lacking.

In summary, while there is a scientific rationale and some preliminary evidence supporting citrulline supplementation for vascular health, the evidence for CAKG specifically to treat or support poor circulation is limited and rates as 2 out of 5.

More about Citrulline alpha-ketoglutarate
More about Circulation (poor)

Other ingredients used for Circulation (poor)

acetyl l-carnitine
ajoene
algal oil
alpha-linolenic acid (ALA)
amino acids
anthocyanins
arjun tree
ashwagandha
asparagus
astaxanthin
astragalus
beet
bergamot
berry flavor
bilberry
black cumin
black currant
black garlic
black pepper
sesame
black tea
blueberry
bromelain
bupleurum falcatum
burdock
butcher's broom
caffeine
capsaicinoids
cat's claw
caterpillar mushroom
celery
chen pi
cherry
Chinese salvia root
chokeberry
cinnamon
citrus bioflavonoids
citrus sinensis (proprietary)
clove
coenzyme Q10 (CoQ10)
coleus forskohlii
cordyceps
turmeric
curcumin
d-alpha tocopherol
DHA (docosahexaeonic acid)
diallyl disulfide (DADS)
diallyl trisulfide (DATS)
dong quai root
eleuthero
EPA (eicosapentaenoic acid)
fish oil
fish protein
flavonols
flaxseed
fruit and vegetable blend (proprietary)
garlic bulb
ginger
ginkgo biloba
ginseng
gooseberry
gotu kola
grape
onion
green tea
greens blend (proprietary)
hawthorn
hesperetin
hesperidin
hibiscus
horse chestnut
horseradish
Indian tinospora
iron
knotweed
kudzu
l-arginine
l-carnitine
l-citrulline
lovage
mackerel
magnesium
marine lipid
moringa
mustard seed
naringin
nattokinase
nettle
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
orange
oyster mushroom
pine bark
policosanol
pomegranate
quercetin
redcurrant
reishi mushroom
resveratrol
rhizome
rose hips
rosemary
rutin
safflower oil
sardines
shiitake mushroom
black ginger
spinach
tocotrienols
triphala
ubiquinol
vegetable and fruit blend (proprietary)
vegetable blend (proprietary)
vitamin B
vitamin E
seaweed
water
watercress
watermelon
mulberry
sarsaparilla
suma
jiaogulan
tangerine
gastrodia
cardamom
atractylodes
capsicum
Indian bael
inula racemosa
punarnava
commiphora
smilax
blackboard tree
caesalpinia crista
peony
lingzhi
lingusticum wallichii
prickly ash
siler root
cistanche
dioscorea
dodder
ganoderma
morinda
zanthoxylum
birch
polyphenols
purslane
yerba mate
biota seed
goji berry
herbal blend (proprietary)
Sichuan pepper
yohimbe
cocoa
AMP-activated protein kinase (AMPK)
enzymes blend (proprietary)
cayenne pepper
ashitaba
2-(nitrooxy)ethyl 2-amino-3-methylbutanoate
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Aralia
Arjuna
Arginine Alpha Ketoglutarate
Antler
Autumn elaeagnus
Arginine Creatine
Arginine nitrate
Angelica
Aronia melanocarpa
Allicin
Arginine aspartate
Achyranthes
Auricularia
Adrenergic amines
Alpha-Lipoic Acid
Astragaloside
anthocyanidins
Asteracea
Arjunic Acid
Alliin
anthocyanosides
Allium tuberosum
Arginine silicate
Atractylone
Bishop's Weed
Butea monosperma
Black galingale
berry
Bur-Reed
Bioflavonoids
Bee products
Buddha's Hand
Buckwheat
Bassia scoparia
Boerhavia diffusa
Borneol
Coumarin
Centella triterpenes
Chinese Silkvine
Cinnamomum
Chinese Mountain Ant
Carqueja
Calycosin
Capsinoids
Codonopsis
Capillary Artemisia
Cyanidin
Curcuminoid
Citrus
Capsaicin
Catecholamine
Cowherb
Curcumen
Centella asiatica
Coca
Chocolate
Curcuma
Chestnut
Cinnamaldehyde
Costus
Carthamus
cola nut
Currant
Diallyl sulfide
Diosmin
Dismutase
Danshen
Dong Quai
Date
Diosmetin
Dodeca-2E, 4E, 8Z, 10Z/Etetraenoic Acid Isobutylamide
epicatechin
Eupolyphaga sinensis
Elk antler
Evodiamine
Eicosapentaenoic Acid
Essential Oil Blend
Ephedrine
Ethylenediaminetetraacetic acid (EDTA)
European-Five Finger Grass
Echium
Fruit
Flavonoids
Fo-Ti
Flat-stem milk-vetch
Fatty acids
Flavanones
Fagopyrum
Flavoglycosides
Flavans
Forskolin
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Flavones
Ginsenosides
Glycoside
Garlic
Ginkgo Flavone Glycoside
Mustard
Mistletoe
Pistachio
Sumac
Sweet Orange alcohol
yohimbine
Zucchini

Other health conditions supported by Citrulline alpha-ketoglutarate

Athletic and Exercise Aids
Body Building
Circulation (poor)
Energy (lack of)
Fatigue
Hypertension

Products containing Citrulline alpha-ketoglutarate

We currently have no products on Caring Sunshine that contain this ingredient.