Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-carnosine is a naturally occurring dipeptide with antioxidant and anti-glycation properties. There is some scientific interest in its potential to reduce chemotherapy-induced side effects, primarily due to its ability to scavenge reactive oxygen species and protect normal tissues from oxidative damage. Preclinical studies (in vitro and animal models) suggest that carnosine may help protect non-cancerous cells from the cytotoxic effects of chemotherapy agents, particularly those whose mechanisms involve oxidative stress (e.g., doxorubicin, cyclophosphamide). For example, several rodent studies have demonstrated that carnosine supplementation can decrease markers of organ toxicity (such as cardiotoxicity or nephrotoxicity) caused by certain chemotherapeutic drugs.

However, clinical evidence in humans remains very limited. There are no large, well-controlled randomized trials definitively demonstrating that carnosine supplementation meaningfully reduces chemotherapy side effects or improves patient outcomes. A few small pilot studies and case reports have explored its use, but the results are preliminary and not conclusive.

In summary, while there is a scientific rationale and some preclinical evidence supporting the use of L-carnosine to mitigate chemotherapy side effects, the current level of clinical evidence is weak (rated 2/5). More robust clinical trials are needed to clarify its efficacy and safety in this context.

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