Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Zeaxanthin is a carotenoid found in high concentrations in the macula of the human eye and is commonly used as a dietary supplement to support ocular health, including the prevention and management of cataracts. The scientific rationale for its use is based on its antioxidant properties and its ability to filter harmful blue light, which may help protect lens proteins from oxidative damage—a key factor in cataract formation. Several observational studies have reported an association between higher dietary intake or blood levels of zeaxanthin (often grouped with lutein) and a reduced risk of age-related cataracts. For example, data from the Nurses’ Health Study and other large cohorts suggest individuals with higher intake of these carotenoids have a lower risk of developing certain types of cataracts, particularly nuclear cataracts.

However, randomized controlled trials (RCTs) directly investigating zeaxanthin supplementation for cataract prevention or treatment are limited. The Age-Related Eye Disease Study 2 (AREDS2), a major clinical trial, primarily evaluated the role of lutein and zeaxanthin in age-related macular degeneration but did not show a significant reduction in cataract surgery rates with supplementation. Overall, while the biological plausibility is strong and observational data are somewhat supportive, the direct clinical evidence from intervention trials remains inconclusive. Thus, the evidence supporting zeaxanthin for cataract prevention or treatment is modest (rating: 2/5), and more high-quality RCTs are needed to confirm its efficacy.

More about Zeaxanthin
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Other ingredients used for Cataracts

Other health conditions supported by Zeaxanthin

Products containing Zeaxanthin

Nature's Sunshine Lutein
Nature's Sunshine Perfect Eyes