Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-proline is an amino acid that plays a critical role in the synthesis of collagen, which is a major component of cartilage tissue. Collagen provides structural integrity and elasticity to connective tissues, including cartilage. The rationale for using L-proline to support or treat cartilage damage primarily stems from its biological role: proline is required for proper collagen formation, and thus, adequate levels are necessary for cartilage repair and maintenance. Some in vitro and animal studies have demonstrated that supplemental L-proline can enhance collagen synthesis and potentially facilitate tissue repair. However, direct clinical evidence in humans demonstrating that L-proline supplementation alone meaningfully improves cartilage repair or reduces symptoms of cartilage damage is limited. Most research focuses on overall protein or collagen supplementation, rather than isolated L-proline. Furthermore, the human body can typically synthesize sufficient L-proline under normal conditions, so the benefit of additional supplementation is unclear except perhaps in cases of metabolic stress or deficiency. While the scientific rationale is plausible based on biochemistry, the direct evidence supporting L-proline’s efficacy for treating cartilage damage in humans is weak to moderate. As such, while its use is scientifically informed, the level of supporting clinical evidence is currently modest, warranting a rating of 2 out of 5.

More about l-proline
More about Cartilage Damage

Other ingredients used for Cartilage Damage

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Products containing l-proline

Nature's Sunshine Free Amino Acids
Nature's Sunshine Target TS-II Formula
Nature's Sunshine VitaWave