Evidence supporting the use of: Vitamin E (mixed tocopherols/tocotrienols)
For the health condition: Cardiovascular Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E, encompassing tocopherols and tocotrienols, has been studied for its potential role in cardiovascular disease (CVD) prevention and treatment due to its antioxidant properties. The theoretical basis is that oxidative modification of low-density lipoprotein (LDL) cholesterol contributes to atherosclerosis, and antioxidants like Vitamin E could inhibit this process. Observational studies from the 1990s suggested an association between higher Vitamin E intake and lower rates of heart disease. However, large randomized controlled trials (RCTs) such as the HOPE (Heart Outcomes Prevention Evaluation) and the Women's Health Study have not demonstrated a significant benefit of Vitamin E supplementation in reducing major cardiovascular events. Some studies even reported potential harm, such as increased risk of heart failure in specific populations. Meta-analyses and systematic reviews generally conclude that Vitamin E supplementation does not reduce the risk of myocardial infarction, stroke, or cardiovascular mortality in the general population. There is ongoing research regarding tocotrienols, which may have additional biological activities, but clinical evidence remains limited and inconclusive. In summary, while there is a scientific rationale and substantial research, the overall quality of evidence supporting Vitamin E (mixed tocopherols/tocotrienols) for prevention or treatment of CVD is weak, and supplementation is not currently recommended for this purpose by major health organizations.

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Products containing Vitamin E (mixed tocopherols/tocotrienols)

We currently have no products on Caring Sunshine that contain this ingredient.