Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Astaxanthin is a carotenoid pigment found naturally in microalgae, yeast, salmon, trout, krill, shrimp, and other seafood. It has gained attention for its potent antioxidant properties, which are much stronger than those of vitamin E or beta-carotene. Scientific interest in astaxanthin for cardiovascular disease (CVD) stems from its potential to reduce oxidative stress, inflammation, and lipid peroxidation—factors implicated in atherosclerosis and other cardiovascular conditions.

Some preclinical studies and small human trials suggest astaxanthin may help reduce markers of inflammation (such as CRP), lower LDL cholesterol, raise HDL cholesterol, and improve endothelial function. For example, a double-blind, placebo-controlled study in healthy adults showed astaxanthin supplementation improved blood lipid profiles and reduced oxidative stress. Animal studies have shown reduced plaque formation and improved vascular health.

However, robust clinical evidence in humans with diagnosed cardiovascular disease is limited. There are few large-scale randomized controlled trials, and those conducted often have small sample sizes or short durations. As a result, while preliminary data are promising and support a rationale for further research, current scientific evidence for astaxanthin’s use in preventing or treating cardiovascular disease is modest. Leading health organizations do not presently recommend astaxanthin as a standard therapy for CVD.

In summary, astaxanthin has scientific backing for its antioxidant and anti-inflammatory effects, but the quality and quantity of evidence specifically supporting its use for cardiovascular disease are still emerging and not yet strong.

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