Vitex negundo, commonly known as the Chinese chaste tree or Nirgundi, has a long history of use in traditional medicine systems such as Ayurveda and Unani. It is traditionally employed for a range of inflammatory and infectious skin conditions, including carbuncles, which are clusters of boils caused by bacterial infection. Ancient Ayurvedic texts list Vitex negundo as possessing anti-inflammatory, analgesic, and antimicrobial properties. Its leaves are often used as poultices applied directly to affected areas, or as part of herbal formulations for skin eruptions, wounds, and carbuncles.

Scientifically, some in vitro and animal studies support the antimicrobial and anti-inflammatory effects of Vitex negundo extracts, including inhibition of Staphylococcus aureus, which is commonly implicated in carbuncles. However, there is a lack of direct clinical trials or robust scientific studies specifically evaluating its efficacy in the treatment of carbuncles in humans. Most available evidence remains preclinical or anecdotal, based on its traditional use and pharmacological properties identified in laboratory settings. Therefore, the justification for using Vitex negundo in carbuncles is primarily traditional, with limited scientific validation at this time.