Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Proanthocyanidins, a class of polyphenolic compounds found in foods such as grapes, berries, and pine bark, have been researched for their effects on vascular health, including support for capillaries. Several studies have shown that proanthocyanidins, particularly those derived from grape seed extract and French maritime pine bark (Pycnogenol), can help strengthen capillary walls, reduce capillary permeability, and improve microcirculation. These effects are thought to be due to their antioxidant properties and their ability to stabilize collagen and elastin, which are important structural proteins in blood vessel walls. Clinical trials in humans have demonstrated that supplementation with proanthocyanidins can reduce symptoms associated with capillary fragility, such as bruising and edema, particularly in conditions like chronic venous insufficiency and diabetic retinopathy. However, while the evidence is promising, the number and size of high-quality randomized controlled trials are still somewhat limited. Most studies support their use as an adjunct in vascular health, rather than a primary therapy. Overall, the use of proanthocyanidins for capillary support is scientifically justified, with moderate evidence primarily based on mechanistic studies, small clinical trials, and meta-analyses.

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