Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin C has been investigated as an adjunct in cancer treatment, particularly for its potential to reduce side effects of chemotherapy and radiation therapy. Some clinical studies have explored both oral and intravenous (IV) vitamin C administration. The rationale is based on vitamin C's antioxidant properties, which may help protect normal tissues from oxidative damage caused by cancer therapies. Additionally, vitamin C may have roles in immune support and reducing inflammation.

Several small clinical trials and observational studies suggest that high-dose IV vitamin C might improve quality of life, reduce fatigue, and alleviate some chemotherapy-associated side effects like nausea and pain. However, most of these studies have methodological limitations, such as small sample sizes, lack of blinding, and short follow-up periods. Systematic reviews and meta-analyses generally conclude that while vitamin C appears to be safe for most patients, the evidence for efficacy in reducing treatment side effects is inconclusive and not robust.

Major cancer organizations note that vitamin C supplementation is not a substitute for conventional therapy, and high doses, especially IV, should only be given under medical supervision. In summary, there is some emerging scientific interest and a modest evidence base, but further large-scale, high-quality randomized controlled trials are needed to establish clear benefit.

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