Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Microcrystalline hydroxyapatite concentrate (MCHC) is a naturally derived compound obtained from bovine bone, primarily composed of calcium and phosphate in the same ratio as found in human bone, along with trace minerals and bone proteins. MCHC is used as a dietary supplement to support bone health and to address calcium deficiency, particularly in populations at risk for osteoporosis or impaired bone mineralization.

The justification for MCHC use is supported by several scientific studies, though the evidence is not as robust or extensive as that for standard calcium salts like calcium carbonate or citrate. Some clinical trials have demonstrated that MCHC can increase bone mineral density (BMD) and reduce bone loss in postmenopausal women and the elderly, potentially offering advantages over other calcium sources due to its content of additional bone-supportive nutrients such as collagen and growth factors. However, meta-analyses and systematic reviews have noted that while MCHC is effective in increasing BMD, direct evidence for its superiority over conventional calcium supplements is limited.

Mechanistically, MCHC provides a bioavailable source of calcium and phosphate, mimicking the natural matrix of bone, which may enhance absorption and utilization. It is generally recognized as safe when sourced from properly processed bovine bone. Overall, the scientific evidence supports the use of MCHC for calcium deficiency, but more large-scale, long-term studies are needed to fully establish its comparative efficacy.

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