Evidence supporting the use of: Ligustrazin
For the health condition: Bruises (prevention)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Ligustrazin (also known as tetramethylpyrazine) is a compound extracted from the Chinese herb Ligusticum chuanxiong, which has been used in Traditional Chinese Medicine (TCM) for centuries. In TCM, this herb is often prescribed to promote blood circulation and remove blood stasis, a concept linked to conditions like bruising and contusions. The use of Ligustrazin for bruises is therefore rooted primarily in traditional practice rather than modern scientific validation.

While modern pharmacological research has investigated Ligustrazin for cardiovascular and neuroprotective effects, there is limited direct scientific evidence supporting its efficacy for preventing or treating bruises specifically. Most studies focus on its potential to improve microcirculation, reduce platelet aggregation, and inhibit inflammation, which are theoretically relevant to bruise healing but have not been robustly studied in the context of bruise prevention or treatment in humans. As such, while the traditional use is well established, scientific validation for this specific indication is lacking. The overall quality and quantity of evidence supporting its use for bruises can be considered low (rated 2/5), primarily based on tradition and indirect pharmacological rationale rather than direct clinical trials.

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