Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Endo-peptidases, such as bromelain and serrapeptase, are proteolytic enzymes that have been studied for their potential to support the healing of bruises and reduce associated symptoms like swelling and inflammation. The scientific justification stems primarily from their ability to degrade fibrin and other protein debris at sites of tissue injury, theoretically facilitating the resolution of hematomas (bruises) and enhancing microcirculation. Several small clinical trials and preclinical studies suggest that oral administration of these enzymes can modestly reduce post-traumatic edema, pain, and discoloration after injuries, surgeries, or dental procedures. For example, bromelain has been shown in some randomized controlled trials to accelerate the resolution of bruising and swelling compared to placebo. However, the quality of evidence is limited by small sample sizes, heterogeneous study designs, and occasional methodological flaws. Systematic reviews often conclude that while there is some evidence for efficacy, it is not robust or consistent enough to warrant strong recommendations, and more high-quality research is needed. In summary, there is preliminary scientific validation for the use of endo-peptidases in the prevention and treatment of bruises, but the overall strength of evidence is weak to moderate, justifying a rating of 2 out of 5.

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