Peptides, particularly collagen peptides, have scientific validation for their supportive role in bone health and fracture healing. Collagen is the primary protein in bone matrix, and hydrolyzed collagen peptides are thought to support bone regeneration by providing essential amino acids and stimulating osteoblast activity. Several preclinical studies have demonstrated that collagen peptide supplementation can increase bone mineral density and enhance bone healing in animal models. Human data are more limited but promising; a few clinical trials have shown that oral collagen peptide supplementation may improve bone metabolism markers and support bone mineral density, particularly in postmenopausal women susceptible to osteoporosis.

Additionally, some evidence suggests that specific bioactive peptides (such as those derived from milk or eggs) can modulate bone remodeling by influencing osteoclast and osteoblast activity. However, the majority of human studies focus on prevention of osteoporosis rather than direct treatment of acute fractures. There is a lack of large, high-quality randomized controlled trials specifically investigating peptides as a primary treatment for broken bones in humans. Still, the biological rationale and early data are sufficient to support a moderate scientific rating for the use of peptides—especially collagen peptides—in supporting bone healing.