Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Growth factors are biologically active proteins that play a crucial role in the regulation and stimulation of cellular processes, including proliferation, differentiation, and tissue repair. Their use in treating broken bones is scientifically validated, particularly in the context of enhancing and accelerating bone healing. Multiple preclinical and clinical studies have demonstrated that exogenously applied growth factors, such as Bone Morphogenetic Proteins (BMPs) and Platelet-Derived Growth Factor (PDGF), can stimulate osteogenesis (new bone formation), angiogenesis (formation of new blood vessels), and overall bone regeneration.

BMP-2 and BMP-7 are among the most well-studied growth factors for bone healing, with FDA approval for certain clinical applications such as spinal fusions and non-union fractures. Clinical trials have shown that these growth factors can improve bone healing rates, especially in cases where normal healing is impaired or delayed. The use of growth factors is particularly prominent in orthopedic surgery, dental implantology, and reconstructive procedures.

Despite the robust evidence supporting their efficacy, the use of growth factors is associated with certain risks, including inflammation, ectopic bone formation, and high cost, which limits their widespread application. Nonetheless, the scientific foundation for their use in bone repair is strong, and ongoing research continues to refine their delivery methods and safety profiles for broader clinical use.

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