Sicilian Sumac (Rhus coriaria) has been used traditionally in Mediterranean and Middle Eastern folk medicine for a variety of ailments, including infections and inflammatory conditions. The use of sumac to support or treat "blood poisoning" (commonly referring to sepsis or systemic infections) is rooted in traditional practices rather than robust scientific validation. Historical texts and ethnobotanical surveys indicate that sumac was valued for its antimicrobial, astringent, and antioxidant properties, and was sometimes used in poultices or infusions to help with wounds and reduce the risk of infection. However, there is little direct documentation specifically linking sumac to the treatment of blood poisoning in classical medical texts.

Regarding scientific evidence, laboratory studies have confirmed that sumac extracts possess antimicrobial activity against a variety of bacteria and fungi, which could, in theory, support its use in preventing localized infections. However, these findings have not been extended to clinical trials or systemic infections such as sepsis. There is no high-quality clinical evidence demonstrating that Sicilian Sumac can treat or significantly impact blood poisoning in humans. Thus, while the traditional use exists, especially in the context of infection prevention, the evidence supporting its efficacy for blood poisoning is extremely limited and not scientifically validated.