Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Hyperimmune milk peptides are derived from cows that have been immunized with specific antigens, resulting in milk containing higher levels of immunoglobulins and bioactive peptides. There is some emerging scientific interest in their use for immune modulation, including potential application in autoimmune disorders. Preclinical studies and a limited number of small clinical trials suggest that hyperimmune milk may help modulate immune responses, reduce gut inflammation, and improve intestinal barrier function. These effects could theoretically benefit certain autoimmune conditions, particularly those with gastrointestinal involvement like inflammatory bowel disease (IBD).

However, the overall quality of evidence remains low. Most studies have been conducted in vitro or in animal models, with only a few small human trials. The mechanisms are not fully understood, but may involve modulation of cytokine production, support of regulatory T cell populations, and competitive inhibition of pathogenic microbes. There is insufficient large-scale, high-quality clinical evidence to confirm efficacy or safety in autoimmune disorders broadly. Thus, while there is a plausible scientific rationale and preliminary data, the evidence base is weak and not yet robust enough to strongly support routine use for autoimmune conditions.

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