Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha-GPC (L-alpha-glycerylphosphorylcholine) is sometimes used as a supplement to support athletic performance and exercise capacity. The rationale for its use is based on its role as a precursor to acetylcholine, a neurotransmitter involved in muscle contraction and cognitive processes. Some small-scale clinical studies and pilot trials have explored Alpha-GPC's effects on physical performance. For instance, a few studies have reported that Alpha-GPC supplementation (typically 600 mg prior to exercise) may increase growth hormone secretion acutely and potentially enhance power output in resistance-trained athletes, such as increasing bench press force production. However, these studies often have limited sample sizes and short durations. A 2015 randomized, double-blind, placebo-controlled study found a significant increase in lower-body force production after Alpha-GPC supplementation, but other studies have failed to replicate these findings consistently or observed only modest effects. The overall body of evidence remains mixed, with some support for acute improvements in power output and reaction time, but little robust data on long-term enhancements in strength, endurance, or exercise adaptation. In summary, there is some scientific exploration and limited evidence supporting Alpha-GPC as an athletic or exercise aid, but the quality and consistency of the data are not strong. Larger, well-controlled studies are needed to establish its efficacy for this indication.

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