Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Naphthoquinones—a class of organic compounds including agents such as juglone and lapachol—have demonstrated notable antifungal properties in vitro, which forms the scientific basis for their use in treating fungal infections such as Athlete’s Foot (tinea pedis). These compounds are found naturally in certain plants (e.g., walnut, lapacho tree). Laboratory studies have shown that naphthoquinones can inhibit the growth of dermatophytes, including Trichophyton species, which are the primary causative agents of Athlete’s Foot. For example, lapachol and juglone have both been shown to disrupt fungal cell membranes and inhibit spore germination in controlled studies.

However, while the antifungal activity of naphthoquinones is well documented in vitro, clinical studies assessing their efficacy and safety for topical treatment of Athlete’s Foot in humans are limited. There are no large-scale, placebo-controlled clinical trials confirming their effectiveness or establishing optimal dosing and formulation. Most available evidence is preclinical or from small, preliminary studies. As a result, while their use is scientifically plausible and supported by laboratory research, more robust clinical data are needed to fully validate their role in the treatment of Athlete’s Foot.

In summary, naphthoquinones have a scientific rationale for their antifungal application, but the current strength of evidence for their use specifically in Athlete’s Foot rates as moderate (3/5) due to the lack of comprehensive clinical trials.

More about Naphthoquinones
More about Athlete's Foot

Other ingredients used for Athlete's Foot

Other health conditions supported by Naphthoquinones

Products containing Naphthoquinones