Synopsis

Source of validity: Scientific
Rating (out of 5): 2

S-allylcysteine (SAC) is a water-soluble organosulfur compound derived from aged garlic extract. Its use to support or treat arteriosclerosis (the thickening and hardening of arterial walls) is primarily based on recent scientific studies rather than traditional herbal medicine practices. Experimental research, mainly in animal models and a few small clinical studies, suggests SAC may help reduce oxidative stress, inhibit low-density lipoprotein (LDL) oxidation, and improve endothelial function, all of which are factors in the development of arteriosclerosis. SAC is also reported to have anti-inflammatory properties and may influence lipid profiles by lowering cholesterol and triglyceride levels.

Aged garlic extract, which contains SAC as a key active component, has been more extensively studied than isolated SAC. Some clinical trials on aged garlic extract have demonstrated modest benefits in slowing the progression of coronary artery calcification and improving arterial elasticity. However, direct evidence for SAC alone is still limited, and most human studies involve small sample sizes or are preliminary in nature. While the mechanistic data and early clinical evidence are promising, more large-scale, well-controlled human trials are needed to firmly establish SAC's efficacy in preventing or treating arteriosclerosis.

In summary, there is some scientific evidence, but it is not robust; thus, the evidence rating is 2 out of 5.

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