Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Hesperetin is a flavonoid primarily found in citrus fruits, and its use for supporting or treating arteriosclerosis is justified by some degree of scientific evidence, though it is still largely preclinical. Several in vitro and animal studies suggest that hesperetin exerts anti-atherosclerotic effects through multiple mechanisms. These include antioxidant activity, inhibition of LDL oxidation, improvement of endothelial function, and anti-inflammatory properties. For example, research published in Journal of Agricultural and Food Chemistry (2008) and Phytotherapy Research (2014) demonstrated that hesperetin supplementation reduces lipid accumulation in arterial walls, suppresses inflammatory cytokines, and enhances nitric oxide production, all of which are beneficial in the context of arteriosclerosis. However, the bulk of this evidence stems from laboratory and animal model studies, with limited clinical trials in humans. The few human studies available focus on hesperidin (the glycoside form of hesperetin) and show some improvements in vascular function and blood lipid profiles, but these are small-scale and not specific to established arteriosclerosis. Thus, while the mechanistic rationale is strong and early data are promising, more robust clinical trials are needed to firmly establish hesperetin’s efficacy for arteriosclerosis in humans. Its use is therefore scientifically plausible, but not yet strongly validated in clinical settings.

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