Evidence supporting the use of: Vitamin D
For the body system: Arteries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin D has garnered scientific interest for its potential role in supporting arterial and overall cardiovascular health. Observational studies have found that low serum vitamin D levels are associated with an increased risk of hypertension, atherosclerosis, and other cardiovascular diseases. Mechanistically, vitamin D receptors are present in vascular smooth muscle, endothelium, and cardiomyocytes, suggesting a possible direct effect on the arterial system. Vitamin D is believed to modulate inflammation, regulate the renin-angiotensin-aldosterone system (which controls blood pressure), and influence vascular calcification. Some studies suggest that adequate vitamin D status may help maintain endothelial function and reduce arterial stiffness.

However, while the association between vitamin D deficiency and cardiovascular risk is well supported by observational research, randomized controlled trials (RCTs) on vitamin D supplementation have produced mixed results. Some RCTs have shown minor benefits on blood pressure or arterial stiffness in deficient populations, but most large trials have not demonstrated a significant reduction in major cardiovascular events with supplementation in the general population. Therefore, while vitamin D is important for overall health and correcting deficiency is essential, the evidence that supplementation directly supports arterial health or prevents arterial disease is moderate and not definitive.

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asiaticoside
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