Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Tocotrienols are members of the vitamin E family, distinct from tocopherols due to their unsaturated side chain. Their use to support arterial and cardiovascular health has some scientific basis, though the overall quality and quantity of evidence is moderate. Preclinical and some human studies suggest that tocotrienols may help reduce cholesterol levels, inhibit oxidative stress, and suppress inflammation—factors relevant to arterial health. For instance, several randomized controlled trials have shown that tocotrienol-rich fractions can lower LDL cholesterol and total cholesterol in hypercholesterolemic individuals, although results are not always consistent. Animal and cell studies demonstrate that tocotrienols can inhibit HMG-CoA reductase (the target of statin drugs), reduce arterial plaque formation, and decrease markers of oxidative damage.

However, large-scale clinical trials are lacking, and some human studies show minimal or no effect on cholesterol or arterial outcomes, limiting the strength of the evidence. Additionally, most research uses tocotrienol-rich fractions rather than isolated tocotrienols, which can complicate interpretation. Despite these limitations, the antioxidant and cholesterol-lowering properties observed in controlled settings offer a plausible mechanism for arterial support. Overall, tocotrienols show promise, but more robust human data are needed before their use for arterial health can be strongly recommended.

More about tocotrienols
More about Arteries

Other ingredients that support Arteries

Other body systems supported by tocotrienols

Products containing tocotrienols

Nature's Sunshine Super Antioxidant