Evidence supporting the use of: Indian snakeroot
For the health condition: Anxiety

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Synopsis

Source of validity: Traditional
Rating (out of 5): 3

Indian snakeroot (Rauwolfia serpentina) has a long history of use in traditional Ayurvedic medicine for a variety of nervous and mental disorders, including anxiety, insomnia, and agitation. The root contains several active alkaloids, most notably reserpine, which was isolated and studied extensively in the mid-20th century. Reserpine works by depleting stores of certain neurotransmitters such as serotonin, dopamine, and norepinephrine in the brain, leading to a calming effect. This pharmacological action led to the use of reserpine-derived drugs for hypertension and psychotic disorders in Western medicine during the 1950s and 1960s.

However, while traditional use for anxiety and nervousness is well-documented, modern clinical evidence is limited and somewhat outdated. Some early clinical studies suggested mild sedative and tranquilizing effects, but reserpine is associated with significant side effects, including depression, hypotension, and extrapyramidal symptoms, which has led to a decline in its use for psychiatric indications. Most contemporary guidelines do not recommend Indian snakeroot or reserpine for anxiety due to these safety concerns and the availability of safer alternatives.

In summary, the use of Indian snakeroot for anxiety is primarily justified by traditional practices, with historical scientific interest but insufficient, high-quality contemporary evidence for efficacy and safety. The risk of adverse effects further limits its current clinical application.

More about Indian snakeroot
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Products containing Indian snakeroot

We currently have no products on Caring Sunshine that contain this ingredient.