Evidence supporting the use of: Bacillus (unspecified)
For the health condition: Antibiotics (side effects of)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Bacillus species, particularly Bacillus coagulans and Bacillus subtilis, are spore-forming probiotics that have been studied for their ability to mitigate side effects of antibiotics, specifically antibiotic-associated diarrhea (AAD). Antibiotics disrupt the natural gut microbiota, leading to gastrointestinal symptoms such as diarrhea, bloating, and discomfort. Several randomized controlled trials and meta-analyses have evaluated the efficacy of Bacillus-based probiotics in preventing or reducing AAD. For example, a 2016 meta-analysis (Guo et al., PLOS ONE) found that Bacillus coagulans supplementation significantly reduced the risk of diarrhea in patients receiving antibiotics. Similarly, Bacillus subtilis has shown some positive effects in smaller clinical studies. The main mechanisms proposed include competitive exclusion of pathogenic bacteria, production of antimicrobial substances, and modulation of the host immune response. However, while the evidence is promising, it is not as robust or extensive as that for other probiotics like Lactobacillus or Saccharomyces boulardii. The studies for Bacillus species are fewer, often have small sample sizes, and lack standardization in probiotic strains and dosages. Consequently, while there is scientific validation for the use of Bacillus probiotics to support gut health during antibiotic therapy, the quality and quantity of evidence are moderate, justifying a rating of 3 out of 5.

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