Synopsis

Source of validity: Scientific
Rating (out of 5): 3

17α-dimethyl-bol (commonly known as Methandrostenolone or Dianabol) is an orally active anabolic-androgenic steroid (AAS). Historically, Methandrostenolone and related anabolic steroids have been studied and, in some cases, used as adjunct therapy in certain types of anemia, particularly aplastic anemia. The rationale stems from their ability to stimulate erythropoiesis (red blood cell production) through enhancement of erythropoietin secretion and direct stimulation of the bone marrow. Anabolic steroids like oxymetholone and nandrolone have more extensive documentation and current medical use for some anemic conditions, but Methandrostenolone was also investigated for similar indications in the mid-20th century. However, evidence is limited, and most studies are old, with small sample sizes and modest efficacy. Importantly, the use of 17α-alkylated steroids like Methandrostenolone for anemia has been largely discontinued due to the risk of serious side effects, including hepatotoxicity, and the development of safer and more effective treatments like recombinant erythropoietin. Thus, while there is scientific rationale and some supporting data for its use in treating anemia, it is not a current standard of care and is rarely, if ever, used for this indication today.

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