Evidence supporting the use of: Sodium Butyrate
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Sodium butyrate, a short-chain fatty acid derived from the fermentation of dietary fibers by gut microbiota, has gained interest in Alzheimer's disease (AD) research primarily due to its roles as a histone deacetylase (HDAC) inhibitor and modulator of neuroinflammation. Preclinical studies—in vitro and in animal models—have shown that sodium butyrate can improve cognitive deficits, reduce amyloid-beta accumulation, and modulate neuroinflammatory responses. For example, mouse models of AD treated with sodium butyrate exhibited enhanced memory performance and reduced synaptic loss, likely linked to epigenetic alterations and anti-inflammatory effects. However, as of 2024, there is limited clinical evidence in humans supporting its efficacy for Alzheimer's disease. Most findings are based on animal studies or cellular models, and while the mechanistic rationale is promising—particularly regarding HDAC inhibition and its impact on neuroplasticity—human trials are lacking or in very early stages. Systematic reviews and expert commentaries emphasize the need for robust clinical trials to establish safety, dosing, and effectiveness in AD patients. In summary, while there is a scientific basis for investigating sodium butyrate in Alzheimer's disease, current evidence supporting its use is mostly preclinical, and its clinical utility remains unproven. The evidence strength is rated 2 out of 5, reflecting early-stage but promising research without established clinical validation.

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Products containing Sodium Butyrate

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