Synopsis

Source of validity: Scientific
Rating (out of 5): 1

Creatine is a naturally occurring compound involved in cellular energy metabolism, and its supplementation has been widely studied in the context of athletic performance and muscle disorders. There is growing scientific interest in its potential neuroprotective effects, including in neurodegenerative diseases like Alzheimer’s Disease (AD). The rationale is based on creatine's role in energy homeostasis and mitochondrial function, both of which are compromised in AD. Preclinical studies in animal models have shown that creatine supplementation can reduce oxidative stress, stabilize mitochondrial function, and, in some cases, modestly improve cognitive performance. However, results are inconsistent and not universally positive.

Despite mechanistic plausibility and supportive animal data, evidence in humans is extremely limited. Few clinical trials have investigated creatine for AD or cognitive decline, and those that exist are generally underpowered, show no significant benefit, or remain inconclusive. Systematic reviews and meta-analyses consistently state that there is insufficient evidence to recommend creatine as a treatment or preventive measure for Alzheimer’s Disease. Thus, while the use of creatine in this context is motivated by scientific hypotheses and some laboratory evidence, clinical validation is lacking. It is not a traditional remedy for AD, nor is it a standard or widely recommended intervention.

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