Evidence supporting the use of: Vitamin A (vitamin A acetate)
For the health condition: Aging (prevention)
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Vitamin A (retinol and its derivatives, including vitamin A acetate) has scientific support for its use in skin aging prevention, particularly when applied topically. Vitamin A derivatives, notably retinoids like tretinoin (all-trans retinoic acid), have been extensively studied and are considered among the most effective agents for improving signs of photoaging, such as fine lines, wrinkles, and hyperpigmentation. Retinoids work by modulating gene expression in skin cells, promoting collagen synthesis, increasing epidermal turnover, and reducing the breakdown of extracellular matrix components, which cumulatively help maintain youthful skin appearance.
Oral supplementation of vitamin A is less commonly used for anti-aging due to potential toxicity at high doses and lack of evidence for efficacy in skin aging at standard dietary intakes. Most clinical trials and dermatological applications focus on topical retinoids, which are FDA-approved for photoaged skin. While vitamin A acetate itself is a precursor and used in some cosmetic formulations, its conversion to active retinoic acid in the skin is relatively slow compared to prescription retinoids.
Overall, the anti-aging effects of vitamin A are scientifically validated, particularly through topical application of its derivatives, although not all forms are equally effective. The rating is 3 because the evidence is strong for derivatives (retinoids), but less so for vitamin A acetate itself, and safety concerns limit oral use for this purpose.
More about Vitamin A (vitamin A acetate)
More about Aging (prevention)
Other ingredients used for Aging (prevention)
7-hydroxymatairesinol (HMR)7-Keto-DHEA
acai berry
acetyl l-carnitine
akkermansia muciniphila
algal oil
alpha-carotene
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
alpha-linolenic acid (ALA)
amino acids
anthocyanins
apple
apricot
ascorbyl palmitate
ashwagandha
astaxanthin
astragalus
beta-carotene
brussel sprouts
carrot
catalase
cauliflower
coenzyme Q10 (CoQ10)
collagen
cryptoxanthin
turmeric
curcumin
DHEA (dehydroepiandrosterone)
epigallocatechin gallate (EGCG)
fisetin
flaxseed
ginkgo biloba
green tea
greens blend (proprietary)
l-carnosine
lutein
magnesium
matcha
melatonin
mixed carotenoids
nicotinamide riboside
omega-3 fatty acids
polypeptide complex (proprietary)
protein
quercetin
resveratrol
rhodiola
sardines
selenium
silicon
soybean
trans-pterostilbene
almond fruit
Urolithin A
vegetable blend (proprietary)
vitamin A
vitamin C
vitamin E
watermelon
zinc
β-nicotinamide mononucleotide (NMN)
cistanche
dodder
royal jelly
polyphenols
anemarrhena asphodeloides
yerba mate
goji berry
algae
AMP-activated protein kinase (AMPK)
soy isoflavones
ashitaba
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
8-Prenylnaringenin
Antler
Apigenin
Aronia melanocarpa
Antrodia camphorata
Anserine
Avocado
Alpha Hydroxy Acids
Allantoin
Alpha-Lipoic Acid
Astragaloside
anthocyanidins
Ampelopsin
Algal protein
anthocyanosides
Argan nut oil
Abalone
Brassica
Bioflavonoids
Bird's nest
Carnosine
Curcuminoid
Cruciferous
Cycloastragenol
Chinese Ligustrum berry
Carotene (unspecified)
Dunaliella salina
Dismutase
DHEA
Dunaliella
Epidermal Growth Factor
epicatechin
Ellagic Acid
Ergothioneine
Flavonoids
Fo-Ti
Fucoxanthin
fibroblast growth factor
Ginsenosides
Gac
Gerovital H3
Glabridin
Other health conditions supported by Vitamin A (vitamin A acetate)
AcneAge Spots
Aging (prevention)
Anemia
Burns and Scalds
Cuts
Diarrhea
Eye Infections
Eye Problems
Eyes (red or itching)
Eyesight (poor)
