Evidence supporting the use of: Vitamin A
For the health condition: Aging (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin A is scientifically recognized for its role in skin health and aging prevention, especially in the form of topical retinoids (like retinol and tretinoin). Retinoids are derivatives of vitamin A and are widely used in dermatology to treat photoaging, fine lines, wrinkles, and hyperpigmentation. Numerous randomized controlled trials and meta-analyses have demonstrated that topical retinoids can stimulate collagen production, accelerate cell turnover, and improve overall skin texture and tone. For example, tretinoin (all-trans retinoic acid) is FDA-approved for reducing fine wrinkles, mottled hyperpigmentation, and roughness of facial skin due to chronic sun exposure. These effects are believed to be mediated through increased collagen synthesis and decreased matrix metalloproteinase activity, which helps maintain the structural integrity of the skin.

Oral vitamin A supplementation, on the other hand, is not commonly recommended for aging prevention in healthy individuals, as excessive intake can be toxic and lead to adverse effects. Most scientific support for vitamin A in aging prevention pertains to its topical use rather than oral supplementation. Historically, vitamin A–rich foods have been associated with good skin health, but modern anti-aging regimens focus on topical applications for direct efficacy.

In summary, there is solid scientific evidence (rating: 3) supporting the use of topical vitamin A derivatives for the prevention and treatment of aging-related skin changes, though oral supplementation is not generally advised for this purpose.

More about vitamin A
More about Aging (prevention)

Other ingredients used for Aging (prevention)

7-hydroxymatairesinol (HMR)
7-Keto-DHEA
acai berry
acetyl l-carnitine
akkermansia muciniphila
algal oil
alpha-carotene
alpha-glycosyl isoquercitrin
alpha-ketoglutarate (AKG)
alpha-linolenic acid (ALA)
amino acids
anthocyanins
apple
apricot
ascorbyl palmitate
ashwagandha
astaxanthin
astragalus
beta-carotene
brussel sprouts
carrot
catalase
cauliflower
coenzyme Q10 (CoQ10)
collagen
cryptoxanthin
turmeric
curcumin
DHEA (dehydroepiandrosterone)
epigallocatechin gallate (EGCG)
fisetin
flaxseed
ginkgo biloba
green tea
greens blend (proprietary)
l-carnosine
lutein
magnesium
matcha
melatonin
mixed carotenoids
nicotinamide riboside
omega-3 fatty acids
polypeptide complex (proprietary)
protein
quercetin
resveratrol
rhodiola
sardines
selenium
silicon
soybean
trans-pterostilbene
almond fruit
Urolithin A
vegetable blend (proprietary)
vitamin A
vitamin C
vitamin E
watermelon
zinc
β-nicotinamide mononucleotide (NMN)
cistanche
dodder
royal jelly
polyphenols
anemarrhena asphodeloides
yerba mate
goji berry
algae
AMP-activated protein kinase (AMPK)
soy isoflavones
ashitaba
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
8-Prenylnaringenin
Antler
Apigenin
Aronia melanocarpa
Antrodia camphorata
Anserine
Avocado
Alpha Hydroxy Acids
Allantoin
Alpha-Lipoic Acid
Astragaloside
anthocyanidins
Ampelopsin
Algal protein
anthocyanosides
Argan nut oil
Abalone
Brassica
Bioflavonoids
Bird's nest
Carnosine
Curcuminoid
Cruciferous
Cycloastragenol
Chinese Ligustrum berry
Carotene (unspecified)
Dunaliella salina
Dismutase
DHEA
Dunaliella
Epidermal Growth Factor
epicatechin
Ellagic Acid
Ergothioneine
Flavonoids
Fo-Ti
Fucoxanthin
fibroblast growth factor
Ginsenosides
Gac
Gerovital H3
Glabridin