Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Vitamin A (including its ester form, vitamin A palmitate) has traditionally been used in skincare for various purposes, including improving skin appearance, texture, and tone. Its use for age spots, also known as liver spots or solar lentigines, is largely rooted in its broader reputation for supporting skin health and encouraging cell turnover. Historically, vitamin A derivatives—especially retinoids, which are stronger, prescription-strength forms—have shown some efficacy in reducing hyperpigmentation and promoting skin renewal. However, vitamin A palmitate is a much milder, over-the-counter form and has not been robustly studied for the specific treatment of age spots. While there is limited scientific evidence that vitamin A palmitate itself can significantly lighten age spots, it is sometimes included in topical formulations with the intent to gently exfoliate and support skin cell turnover, which in theory could help fade dark spots over time. Most clinical evidence supporting vitamin A for hyperpigmentation and age spots is based on studies of retinoic acid (tretinoin), not vitamin A palmitate. Therefore, while traditional cosmetic use persists, the scientific basis for using vitamin A palmitate specifically for age spots is weak, and any benefits are likely to be mild compared to prescription retinoids.

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