Evidence supporting the use of: Licorice (unspecified)
For the body system: Adrenal Glands

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Licorice (Glycyrrhiza glabra) has a long history of use in traditional medicine systems, such as Traditional Chinese Medicine (TCM) and Ayurveda, for supporting the adrenal glands and addressing issues related to fatigue and stress. In TCM, licorice is often included in formulas intended to harmonize and strengthen "Qi," which can be interpreted as supporting overall vitality and resilience, including the body's stress response. The rationale in traditional systems is that licorice root helps the body adapt to stress and restore balance.

Scientifically, there is some evidence that licorice contains glycyrrhizin, a compound that can inhibit the breakdown of cortisol, the body’s primary stress hormone produced by the adrenal glands. By inhibiting the enzyme 11β-hydroxysteroid dehydrogenase, licorice may help prolong the action of endogenous cortisol. However, clinical evidence specifically demonstrating licorice’s ability to “support” adrenal gland function in people with adrenal fatigue or insufficiency is limited and not robust. The majority of modern research focuses on licorice’s effects on cortisol metabolism and its potential side effects, such as increased blood pressure and hypokalemia, rather than direct adrenal support.

In summary, licorice’s use for adrenal support is primarily based on tradition, with some plausible biochemical mechanisms but limited direct clinical evidence.

More about Licorice (unspecified)
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Products containing Licorice (unspecified)

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