Xantinol Nicotinate
Synopsis of Xantinol Nicotinate
History
Xantinol Nicotinate is a compound formed by the combination of xanthinol, a derivative of theophylline, and nicotinic acid (niacin, vitamin B3). Its historical use in medicine dates back to the mid-20th century, particularly in Europe, where it was recognized for its vasodilatory and circulatory benefits. Xantinol Nicotinate has long been valued for its ability to enhance blood flow, especially in the microcirculation, making it a popular remedy for conditions such as peripheral vascular disease, cerebrovascular insufficiency, and memory impairments linked to poor brain perfusion.
Traditionally, this ingredient was prescribed to improve oxygen and nutrient delivery to tissues, supporting overall vitality and cognitive function. Xantinol Nicotinate’s unique mechanism—combining the vasodilatory effects of niacin with the metabolic stimulation provided by xanthinol—helped to alleviate symptoms like cold extremities, dizziness, and intermittent claudication. Its positive impact on circulation also led to its use in managing certain skin disorders and promoting wound healing.
In herbal and nutritional combinations, Xantinol Nicotinate has been paired with botanical extracts such as Ginkgo biloba, hawthorn, and gotu kola. These synergistic blends aimed to further enhance vascular health, cognitive performance, and energy levels. The inclusion of Xantinol Nicotinate in such formulas underscores its reputation as a reliable circulatory support agent, contributing to holistic well-being. Over the decades, its continued presence in nutritional products is a testament to its enduring value in supporting healthy blood flow and overall quality of life.
Traditional and scientific validation
Xantinol Nicotinate is a compound formed by combining xanthinol (a derivative of theophylline) and nicotinic acid (vitamin B3, also known as niacin). Historically, it has been used in Europe and parts of Asia as a vasodilator and nootropic agent, particularly for improving peripheral and cerebral blood flow. Xantinol nicotinate has been included in various nutritional products, primarily aimed at supporting vascular health and cognitive function.
Scientific interest in xantinol nicotinate began in the mid-20th century, with early studies suggesting that the compound could enhance blood circulation and oxygen delivery to tissues. Some clinical trials, especially in the 1960s and 1970s, investigated its potential to alleviate symptoms of vascular insufficiency, such as intermittent claudication and memory disturbances associated with cerebrovascular conditions. Results from these studies often indicated improvements in subjective symptoms and some objective measures of blood flow, although methodologies were not always rigorous by modern standards.
More recent reviews acknowledge that while xantinol nicotinate demonstrates a promising pharmacological profile—combining the vasodilatory effects of niacin with the adenosine receptor-mediated actions of xanthinol—large, well-controlled clinical studies are limited. Its safety profile is generally considered favorable, with mild and transient side effects. While definitive proof of efficacy for all claimed benefits is lacking, xantinol nicotinate continues to be valued in some regions for its supportive role in vascular health. Further research is needed to conclusively establish its clinical benefits, but its long history of use and positive anecdotal reports highlight its potential as a functional ingredient in nutritional products.
Xantinol Nicotinate is used for these health conditions
Angina (Traditional)
Arteriosclerosis (Traditional)
Blood Clots (prevention of) (Traditional)
Cardiovascular Disease (Traditional)
Circulation (poor) (Traditional)
Circulation (to the brain) (Traditional)
Cold Hands and Feet (Traditional)
Hypertension (Traditional)
Phlebitis (Traditional)
Raynaud's Disease (Traditional)
Spider Veins (Traditional)
Thrombosis (Traditional)
Varicose Veins (Traditional)
Xantinol Nicotinate is used to support these body systems
Arteries (Scientific)
Blood (Scientific)
Capillaries (Scientific)
Circulatory System (Scientific)
Heart (Scientific)
