Phosphatidylethanolamine
Other names for Phosphatidylethanolamine
16% as phosphatidyl ethanolamine
20% phosphatidylethanolamine
5% as phosphatidyl ethanolamine
acetylated phosphatidylethanolamine
cephalin
cephaline
cephalins
ethanolamine
glycerophosphatidylethanolamine
gpe
pe 40%
{phosphatidyl}-ethanolamine
phosphatidyl ethanolamine
phosphatidyl-ethanolamine
phosphatidylethanolamine
phosphotidyl ethanalomine
pte
Synopsis of Phosphatidylethanolamine
History
Phosphatidylethanolamine (PE) is a naturally occurring phospholipid commonly found in the membranes of cells throughout the human body. Although its modern prominence is tied to nutritional supplements and functional foods, PE has a rich history of use rooted in the broader context of phospholipids and lecithin, from which it is often derived. Historically, lecithin-rich sources such as soybeans, egg yolks, and sunflower seeds have been used in traditional remedies for supporting brain health, enhancing memory, and promoting overall vitality. Early 20th-century practitioners recognized the value of these substances in boosting cognitive function and aiding in the management of age-related memory decline, long before the specific identification of PE as an active component.
In herbal medicine, phosphatidylethanolamine is frequently incorporated into complex herbal formulations designed to support mental clarity and nervous system health. It is often blended with botanicals like Ginkgo biloba, Bacopa monnieri, and Panax ginseng, which are celebrated for their neuroprotective and adaptogenic properties. These combinations are believed to synergistically enhance the bioavailability and efficacy of herbal remedies, contributing to improved cognitive performance, better mood regulation, and increased resistance to stress.
Today, the positive contributions of phosphatidylethanolamine in nutritional science are widely acknowledged. Its roles in maintaining cell membrane integrity, facilitating neurotransmitter function, and supporting lipid metabolism all underscore its importance in human health. By bridging the gap between traditional remedies and modern nutraceuticals, phosphatidylethanolamine continues to be a valuable component in promoting holistic wellness.
Traditional and scientific validation
Phosphatidylethanolamine (PE) is a naturally occurring phospholipid commonly found in cell membranes, particularly within nervous tissue and various organ systems. Historically, its presence has been noted as crucial for maintaining membrane integrity, fluidity, and cellular signaling. In nutritional products, PE is often included as part of lecithin or specialized phospholipid complexes, drawing interest for its potential benefits in cognitive and metabolic health.
Scientifically, PE plays a significant role in membrane fusion, autophagy, and the assembly of lipoproteins. Preclinical studies suggest that adequate levels of PE may support neuronal health, potentially impacting memory and learning processes. Some small-scale clinical trials and animal studies have explored phospholipids, including PE, in the context of cognitive performance and liver function, with indications of supportive effects, though direct, large-scale human research on isolated PE remains limited.
The nutritional supplementation of PE is generally considered safe, and it may contribute positively to the maintenance of healthy cell membranes and metabolic processes. While definitive, large-scale clinical validation of its standalone effects is still pending, the foundational biological roles of PE support its inclusion in formulations targeting overall cellular and cognitive health. Continued research is warranted to fully establish its therapeutic potential, but current scientific understanding underscores its value as a component of comprehensive nutritional strategies.
Phosphatidylethanolamine is used to support these body systems
Brain (Scientific)
Mitochondria (Scientific)
Nerves (Scientific)
Additional Help
Not sure if this ingredient is right for you?
Talk to Dr. Shannyn, our licensed naturopathic doctor, for a personalized consult. She’ll help you understand how this ingredient fits your unique health goals, lifestyle, and symptoms.
Schedule Your Free Consult →
It’s completely free—no obligation, just support.
Want to know if your body really needs this ingredient?
Explore our at-home lab tests—from hormone and gut panels to toxin screenings. These simple kits give you data to back your decisions, and pair perfectly with natural ingredient guidance.
Explore Lab Testing Options →
Make confident health choices with real insight.