Peptidase (DPPIV) (Dipeptidyl Peptidase IV (DPPIV))
Synopsis of peptidase (DPPIV)
Peptidase, specifically dipeptidyl peptidase IV (DPP-IV), is a serine protease enzyme that breaks down specific peptides in the body by removing dipeptides from the N-terminal end of proteins—particularly when proline or alanine is in the penultimate position. It plays a vital role in both digestion and immune regulation, and is produced in the small intestine, kidneys, and immune cells. In supplement form, DPP-IV enzymes are used to assist individuals who have difficulty digesting gluten (gliadin) and casein—proteins commonly found in wheat and dairy.
Medicinally, DPP-IV enzyme supplements are most often used to support individuals with gluten sensitivity, autism spectrum disorders, or digestive issues involving incomplete protein breakdown. While DPP-IV is not a replacement for a gluten-free diet in celiac disease, it may reduce the impact of accidental gluten exposure by breaking down immunogenic peptides before they trigger an inflammatory response. DPP-IV also helps reduce post-meal brain fog, gas, bloating, and behavioral changes sometimes seen in those with gluten or casein intolerance.
In the pharmaceutical world, DPP-IV inhibitors (not to be confused with enzyme supplements) are a class of drugs used in type 2 diabetes management. These drugs inhibit the breakdown of incretin hormones, helping to regulate blood sugar by increasing insulin secretion and decreasing glucagon levels. While this is a different mechanism from the supplemental enzyme’s role in digestion, it highlights DPP-IV’s broader metabolic importance.
Historical Use in Medicine
DPP-IV was identified and studied in the mid-20th century during advances in protein chemistry and immunology. Unlike many plant-based enzymes (such as bromelain or papain), DPP-IV has no known use in ancient herbal traditions because it is a highly specific, modern, purified enzyme discovered through biochemical research.
The application of DPP-IV supplements in natural health emerged in the early 2000s, particularly through autism research and gluten-sensitive populations. It became a focus in biomedical approaches to autism, where children with suspected “leaky gut” or caseomorphin/gluteomorphin sensitivity were observed to respond positively to DPP-IV enzyme support.
Peptidase (DPPIV) is used for these health conditions
Diabetes (Scientific)
peptidase (DPPIV) is used to support these body systems
Gastrointestinal Tract (Scientific)
Intestinal System (Scientific)
Small Intestines (Scientific)
