L-histidine

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Other names for l-histidine

Free-Form L-Histidine
L-Histidine HCl
Essential Amino Acid (for infants and some adults)

Synopsis of l-histidine

L-Histidine is an essential amino acid, meaning it must be obtained through the diet because the body cannot synthesize it. It plays a crucial role in protein synthesis, enzyme activity, and the production of histamine, a vital neurotransmitter involved in immune responses, stomach acid secretion, and allergic reactions. L-histidine is also a precursor to carnosine, a dipeptide involved in muscle function, antioxidant defense, and age-related tissue preservation.

L-histidine is essential for maintaining normal growth, tissue repair, and cellular regeneration. It plays a critical role in nervous system function, helps maintain pH balance, and is involved in the metabolism of heavy metals. It is also an important amino acid in the production of hemoglobin and is vital for oxygen transport in the blood.

L-histidine is found in protein-rich foods like meat, fish, dairy, eggs, and legumes. It is particularly important for individuals in growth phases, such as children or pregnant women, as well as those recovering from illness or surgery.

Historical Use
L-histidine was first identified as an amino acid in the early 20th century, but its specific biochemical functions were not fully understood until more recent research. Historically, high-protein foods rich in L-histidine, such as meat and dairy, were seen as vital for maintaining energy, immune function, and tissue repair.

L-histidine’s role in immune function and its ability to produce histamine has been acknowledged in traditional medicine systems, where it was linked to allergy management and gastrointestinal health. In modern medical science, L-histidine has gained attention for its role in muscle health, brain function, and antioxidant defense, particularly in sports nutrition and neuroprotection.

Modern Use
L-histidine is widely recognized for its contributions to overall health and well-being, particularly in the following areas:

  • Histamine production: L-histidine is the precursor to histamine, which is important for regulating immune responses, inflammatory reactions, and allergic responses. Histamine is also involved in gastric acid secretion, promoting digestion.
  • Muscle health: L-histidine is used to support muscle recovery and performance by helping to synthesize carnosine, which buffers lactic acid in muscles during exercise, reducing muscle fatigue and enhancing endurance.
  • Antioxidant properties: L-histidine is a component of carnosine, an antioxidant that helps protect against oxidative stress and age-related damage, particularly in the brain, muscles, and eyes.
  • Nervous system support: L-histidine supports brain function and is involved in neurotransmitter regulation. It also plays a role in maintaining myelin sheaths around nerve cells, which are critical for nerve signal transmission.
  • Immune function: L-histidine helps in the production of red blood cells and the maintenance of immune system health, as well as supporting wound healing and tissue repair.

L-histidine is commonly used in amino acid supplements, sports nutrition products, and immune support formulas. It can be found in capsules, tablets, powdered supplements, and is sometimes included in protein blends designed to support muscle recovery and exercise performance.

Safety Considerations
L-histidine is generally considered safe when obtained from dietary sources or supplements at appropriate dosages. However, high doses of histidine may cause gastrointestinal issues, such as nausea, vomiting, or diarrhea. Excessive histamine production can also potentially lead to allergic reactions or increased inflammation.

Before supplementing with L-histidine, it’s recommended to consult a healthcare provider, especially for individuals with histamine intolerance, allergic conditions, or those taking medications that affect histamine levels.

L-histidine is used for these health conditions

Skin Care (general) (Scientific)
Wounds and Sores (Scientific)

l-histidine is used to support these body systems

Blood (Scientific)
Skin (Scientific)