Diallyl disulfide (DADS) (diallyl disulfide)
Synopsis of diallyl disulfide (DADS)
Diallyl disulfide (DADS) is a biologically active organosulfur compound derived from garlic (Allium sativum), especially when garlic is crushed, chopped, or aged. It is formed through the enzymatic breakdown of alliin into allicin, which then further decomposes into diallyl sulfides, including DADS. This compound is responsible for many of garlic’s distinct odor, flavor, and potent health effects.
DADS is known for a wide range of therapeutic properties, including:
- Anti-inflammatory effects by suppressing pro-inflammatory enzymes and cytokines
- Antioxidant activity that helps scavenge free radicals and protect cells from oxidative damage
- Antimicrobial action against bacteria, viruses, and fungi
- Cardioprotective benefits, including lowering blood pressure, reducing LDL oxidation, and improving circulation
- Anticancer properties, particularly in modulating phase I and phase II detox enzymes, inhibiting tumor growth, and inducing apoptosis in cancer cells
- Neuroprotective effects in laboratory studies, potentially offering defense against neurodegeneration
DADS has been studied for its ability to influence liver enzymes (such as cytochrome P450s), supporting detoxification and possibly reducing the activation of carcinogens. It is also believed to modulate cholesterol metabolism, contributing to garlic’s reputation for supporting heart health.
While DADS can be found in raw garlic, it is most concentrated in aged garlic extract and stabilized garlic supplements, where it contributes to the therapeutic consistency and reduced pungency.
Historical Use
Although diallyl disulfide was not chemically isolated or studied until modern times, its parent plant—garlic—has been one of the most important medicinal herbs in global traditional medicine systems for over 5,000 years.
In Ancient Egypt, garlic was consumed by laborers and soldiers to enhance strength, endurance, and protection against disease. In Ayurveda, garlic (lasuna) was used to reduce inflammation, cleanse the blood, improve digestion, and support heart and immune health. It was considered warming and detoxifying, balancing vata and kapha doshas.
In Traditional Chinese Medicine (TCM), garlic was used to disperse cold, warm the stomach, move qi, and eliminate toxins, especially in cases of intestinal parasites or damp stagnation. It was also valued as a preventive remedy during epidemics.
Though DADS itself wasn't referenced, the therapeutic actions attributed to garlic in traditional medicine—such as antimicrobial, heart protective, and digestive stimulant effects—are now scientifically linked to sulfur compounds like DADS.
Today, DADS is one of the most studied compounds in garlic and is featured in aged garlic extract supplements, which are popular for cardiovascular health, immune support, and antioxidant defense. Its role in modern integrative health reflects a bridge between traditional herbalism and contemporary pharmacological science.
Diallyl disulfide (DADS) is used for these health conditions
Cancer (natural therapy for) (Scientific)
Cancer (prevention) (Scientific)
Cancer Treatment (reducing side effects) (Scientific)
Cholesterol (high) (Scientific)
Circulation (poor) (Scientific)
Diabetes (Scientific)
Fatty Liver Disease (Scientific)
Hypertension (Scientific)
Infection (bacterial) (Scientific)
Infection (viral) (Traditional)
Inflammation (Scientific)
Liver Detoxification (Scientific)
Memory and Brain Function (Scientific)
Pain (general remedies for) (Traditional)
Rheumatoid Arthritis (Scientific)
Staph Infections (Scientific)
Triglycerides (high) (Scientific)
Ulcers (Scientific)
diallyl disulfide (DADS) is used to support these body systems
Arteries (Scientific)
Blood (Scientific)
Brain (Scientific)
Circulatory System (Scientific)
Digestive System (Traditional)
Gastrointestinal Tract (Scientific)
Heart (Scientific)
Immune System (Scientific)
Intestinal System (Scientific)
Liver (Scientific)
Lungs (Traditional)
Spleen (Traditional)
Stomach (Traditional)
